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KOREANEmpowering Drug Discovery with Cutting-Edge Cheminformatics solutions
Fuel innovation in drug discovery with our advanced cheminformatics services. From structure-based virtual screening to precision-driven computer-aided drug discovery, we redefine possibilities, driving breakthroughs and shaping the future of pharmaceutical research.
Unleash Revolutionary Breakthroughs:
At 3BIGS, we offer unparalleled drug discovery services powered by the dynamic field of cheminformatics. Our comprehensive solutions include structure-based virtual screening (SBVS), enabling the exploration of critical biomolecular interactions. Through computer-aided drug discovery (CADD), we harness molecular docking, pharmacophore modeling, and precise molecular similarity calculations to accelerate your research. Our proficiency in de novo design fuels innovation, giving you the power to redefine the limits of pharmaceutical development.
3BIGS Drug Discovery Solutions
Hit-to-Lead Identification
The hit-to-lead (H2L) stage in drug discovery is pivotal in selecting candidates for clinical trials. Over the years, bioinformatics has played a crucial role in optimizing lead molecules. At 3BIGS, our proficiency in computer-aided drug design (CADD) and the expertise of our professionals drive H2L advancements. We enhance potency, selectivity, and physicochemical properties, accelerating your journey towards promising compounds that are ready for clinical evaluation.
Accelerate Lead Discovery: Leverage our advanced cheminformatics techniques to identify lead compounds quickly and efficiently, minimizing the time required for potential drug candidates.
Enhance Drug Efficacy: Our comprehensive analysis ensures the selection of lead molecules with improved efficacy, increasing the likelihood of successful drug development.
Optimize Clinical Potential: We prioritize lead compounds with optimal physicochemical properties, ensuring their suitability for further development and successful clinical trials.
AI-based Lead Optimization
After identifying potential lead molecules, the optimization stage is vital to improve efficacy. 3BIGS employs state-of-the-art AI/ML models, including algorithms like artificial neural networks (ANN) and deep learning (DL), for rigorous analyses. Our AI-integrated approach minimizes the duration and expenses of subsequent drug discovery stages by creating an optimized lead with enhanced therapeutic potential.
Precision Optimization: Harness the power of AI to fine-tune lead compounds for improved binding affinity, selectivity, and safety, accelerating the development process.
Reduce Development Costs: Our AI-driven lead optimization significantly reduces the need for extensive experimental testing, saving time and resources.
Enhance Clinical Success: By optimizing lead compounds early in the drug discovery process, we increase the likelihood of success in later stages, reducing the risk of failure
mRNA/Recombinant Vaccine Development
mRNA vaccines offer high potency, safe administration, and rapid development. At 3BIGS, we leverage AI-integrated approaches to further elevate mRNA vaccine creation. Our cutting-edge techniques maximize efficiency in developing cost-effective vaccines with potential to reshape the vaccine landscape.
Rapid Vaccine Development: Utilize our AI-powered methodologies to accelerate the design and development of mRNA/recombinant vaccines, ensuring swift response to emerging diseases.
Enhanced Vaccine Efficacy: Leverage our expertise to optimize vaccine constructs for improved immunogenicity and efficacy, enhancing protection against target pathogens.
Tailored Vaccine Solutions: Our approach allows customization of vaccine candidates based on specific disease targets, enabling personalized and effective vaccine strategies.
De-novo Drug Design
Exploring structurally similar compounds to existing ligands is a gateway to innovative drug solutions. Through 3BIGS’s AI-powered similarity search algorithms, we are dedicated to designing promising lead compounds with a high probability of success.
Diverse Compound Exploration: Discover novel lead compounds by utilizing AI algorithms to search for structural similarities among existing ligands, uncovering potential drugs for various therapeutic targets.
Efficient Drug Development: Benefit from a more efficient drug discovery process by leveraging our similarity-based approach to quickly identify lead candidates that align with established drug profiles.
Enhanced Success Rate: Our specialized approach increases the chances of successful drug development by focusing on compounds with proven structural similarities to known effective drugs.
Similarity based lead identification and optimization
Exploring structurally similar compounds to existing ligands is a gateway to innovative drug solutions. Through 3BIGS’s AI-powered similarity search algorithms, we are dedicated to designing promising lead compounds with a high probability of success.
Diverse Compound Exploration: Discover novel lead compounds by utilizing AI algorithms to search for structural similarities among existing ligands, uncovering potential drugs for various therapeutic targets.
Efficient Drug Development: Benefit from a more efficient drug discovery process by leveraging our similarity-based approach to quickly identify lead candidates that align with established drug profiles.
Enhanced Success Rate: Our specialized approach increases the chances of successful drug development by focusing on compounds with proven structural similarities to known effective drugs.
Molecular Dynamics Simulations based Lead Optimization
Molecular dynamics simulations (MDS) offer unprecedented insights into lead optimization by delving into atomic-level behaviors. Our MDS service empowers you to select and refine lead molecules for unmatched efficiency.
In-depth Molecular Insights: Gain comprehensive knowledge of molecular interactions, flexibility, and behavior, allowing for informed lead optimization decisions.
Refined Lead Molecules: Use MDS to refine lead compounds based on dynamic behaviors, improving binding interactions and overall drug efficacy.
Accelerated Optimization: Our MDS-based approach accelerates lead optimization by providing accurate predictions of molecular behaviors, leading to faster and more effective drug development.
Quantum chemical approach based lead optimization
The quantum chemical approach offers an advanced understanding of protein-ligand interactions by accounting for all energy contributions to binding. 3BIGS utilizes this method to optimize lead molecules with a focus on successful drug development.
Precise Binding Predictions: Benefit from accurate calculations that consider all relevant energy contributions, leading to more informed decisions in lead optimization.
Enhanced Drug Affinity: Our approach refines lead compounds for improved binding affinity, increasing the likelihood of effective drug-target interactions.
Proven Expertise: Trust our years of experience and deep knowledge in quantum chemical calculations to guide your lead optimization efforts, ensuring the generation of successful drug candidates.
Peptide Design
Peptides offer potent therapeutic options and effective drug delivery solutions. At 3BIGS, our state-of-the-art technology and expertise in working with peptide sequences empower us to generate impactful therapeutics and drug delivery systems tailored to your needs.
Effective Therapeutic Solutions: Utilize our expertise to design and develop peptides with enhanced therapeutic potential, catering to a wide range of disease targets.
Innovative Drug Delivery: Leverage the unique properties of peptides for drug delivery systems that enhance bioavailability and targeted delivery, optimizing treatment outcomes.
Customized Peptide Sequences: Trust our proficiency in peptide design to create tailored sequences that align with your therapeutic goals, driving the development of effective and precise treatments.
Hit-to-Lead Identification
Elevating Potential, Streamlining Success
The hit-to-lead (H2L) stage in drug discovery is pivotal in selecting candidates for clinical trials. Over the years, bioinformatics has played a crucial role in optimizing lead molecules. At 3BIGS, our proficiency in computer-aided drug design (CADD) and the expertise of our professionals drive H2L advancements. We enhance potency, selectivity, and physicochemical properties, accelerating your journey towards promising compounds that are ready for clinical evaluation.
Accelerate Lead Discovery: Leverage our advanced cheminformatics techniques to identify lead compounds quickly and efficiently, minimizing the time required for potential drug candidates.
Enhance Drug Efficacy: Our comprehensive analysis ensures the selection of lead molecules with improved efficacy, increasing the likelihood of successful drug development.
Optimize Clinical Potential: We prioritize lead compounds with optimal physicochemical properties, ensuring their suitability for further development and successful clinical trials.
AI-based Lead Optimization
Innovating Excellence for Enhanced Leads
After identifying potential lead molecules, the optimization stage is vital to improve efficacy. 3BIGS employs state-of-the-art AI/ML models, including algorithms like artificial neural networks (ANN) and deep learning (DL), for rigorous analyses. Our AI-integrated approach minimizes the duration and expenses of subsequent drug discovery stages by creating an optimized lead with enhanced therapeutic potential.
Precision Optimization: Harness the power of AI to fine-tune lead compounds for improved binding affinity, selectivity, and safety, accelerating the development process.
Reduce Development Costs: Our AI-driven lead optimization significantly reduces the need for extensive experimental testing, saving time and resources.
Enhance Clinical Success: By optimizing lead compounds early in the drug discovery process, we increase the likelihood of success in later stages, reducing the risk of failure
mRNA/Recombinant Vaccine Development
Revolutionizing Vaccine Creation
mRNA vaccines offer high potency, safe administration, and rapid development. At 3BIGS, we leverage AI-integrated approaches to further elevate mRNA vaccine creation. Our cutting-edge techniques maximize efficiency in developing cost-effective vaccines with potential to reshape the vaccine landscape.
Rapid Vaccine Development: Utilize our AI-powered methodologies to accelerate the design and development of mRNA/recombinant vaccines, ensuring swift response to emerging diseases.
Enhanced Vaccine Efficacy: Leverage our expertise to optimize vaccine constructs for improved immunogenicity and efficacy, enhancing protection against target pathogens.
Tailored Vaccine Solutions: Our approach allows customization of vaccine candidates based on specific disease targets, enabling personalized and effective vaccine strategies.
De-novo Drug Design
Creating Medicines of the Future with AI
Exploring structurally similar compounds to existing ligands is a gateway to innovative drug solutions. Through 3BIGS’s AI-powered similarity search algorithms, we are dedicated to designing promising lead compounds with a high probability of success.
Diverse Compound Exploration: Discover novel lead compounds by utilizing AI algorithms to search for structural similarities among existing ligands, uncovering potential drugs for various therapeutic targets.
Efficient Drug Development: Benefit from a more efficient drug discovery process by leveraging our similarity-based approach to quickly identify lead candidates that align with established drug profiles.
Enhanced Success Rate: Our specialized approach increases the chances of successful drug development by focusing on compounds with proven structural similarities to known effective drugs.
Similarity based lead identification and optimization
Fostering Novel Drug Development
Exploring structurally similar compounds to existing ligands is a gateway to innovative drug solutions. Through 3BIGS’s AI-powered similarity search algorithms, we are dedicated to designing promising lead compounds with a high probability of success.
Diverse Compound Exploration: Discover novel lead compounds by utilizing AI algorithms to search for structural similarities among existing ligands, uncovering potential drugs for various therapeutic targets.
Efficient Drug Development: Benefit from a more efficient drug discovery process by leveraging our similarity-based approach to quickly identify lead candidates that align with established drug profiles.
Enhanced Success Rate: Our specialized approach increases the chances of successful drug development by focusing on compounds with proven structural similarities to known effective drugs.
Molecular Dynamics Simulations based Lead Optimization
Precision at the Atomic Level
Molecular dynamics simulations (MDS) offer unprecedented insights into lead optimization by delving into atomic-level behaviors. Our MDS service empowers you to select and refine lead molecules for unmatched efficiency.
In-depth Molecular Insights: Gain comprehensive knowledge of molecular interactions, flexibility, and behavior, allowing for informed lead optimization decisions.
Refined Lead Molecules: Use MDS to refine lead compounds based on dynamic behaviors, improving binding interactions and overall drug efficacy.
Accelerated Optimization: Our MDS-based approach accelerates lead optimization by providing accurate predictions of molecular behaviors, leading to faster and more effective drug development.
Quantum chemical approach based lead optimization
Advancing Binding Energy Calculations
The quantum chemical approach offers an advanced understanding of protein-ligand interactions by accounting for all energy contributions to binding. 3BIGS utilizes this method to optimize lead molecules with a focus on successful drug development.
Precise Binding Predictions: Benefit from accurate calculations that consider all relevant energy contributions, leading to more informed decisions in lead optimization.
Enhanced Drug Affinity: Our approach refines lead compounds for improved binding affinity, increasing the likelihood of effective drug-target interactions.
Proven Expertise: Trust our years of experience and deep knowledge in quantum chemical calculations to guide your lead optimization efforts, ensuring the generation of successful drug candidates.
Peptide Design
Unlocking Peptide Potential
Peptides offer potent therapeutic options and effective drug delivery solutions. At 3BIGS, our state-of-the-art technology and expertise in working with peptide sequences empower us to generate impactful therapeutics and drug delivery systems tailored to your needs.
Effective Therapeutic Solutions: Utilize our expertise to design and develop peptides with enhanced therapeutic potential, catering to a wide range of disease targets.
Innovative Drug Delivery: Leverage the unique properties of peptides for drug delivery systems that enhance bioavailability and targeted delivery, optimizing treatment outcomes.
Customized Peptide Sequences: Trust our proficiency in peptide design to create tailored sequences that align with your therapeutic goals, driving the development of effective and precise treatments.
Why Choose 3BIGS
Scientific Excellence and Innovation
At 3BIGS, we stand at the forefront of scientific discovery and innovation. Our team of experts brings together deep knowledge in bioinformatics, cheminformatics, and cutting-edge technologies to redefine the boundaries of drug discovery.
Tailored Solutions
We understand that every project is unique. Our approach involves collaborating closely with our clients to understand their specific needs and tailor our services accordingly, ensuring optimal results.
Advanced Technology Integration
Our services are backed by state-of-the-art technologies and AI-driven methodologies, allowing us to provide accurate predictions, rapid insights, and impactful solutions.
Proven Track Record
Over the years, we have demonstrated our ability to deliver results that drive scientific advancements. Our track record showcases successful projects that have translated into tangible breakthroughs.
End-to-End Support
From initial consultation to project completion, we provide comprehensive support at every step. Our team is dedicated to ensuring that your drug discovery journey is smooth and successful.
Timely Delivery
We understand the importance of meeting deadlines in the fast-paced world of drug discovery. Our efficient workflows and dedicated professionals ensure timely delivery of results without compromising on quality.
Confidentiality and Security
We prioritize the confidentiality of your data and research. Our robust security measures and ethical practices ensure that your intellectual property is protected throughout the collaboration.
Collaborative Partnership
We view our clients as partners in scientific exploration. Our collaborative approach fosters open communication, shared insights, and a joint commitment to achieving breakthroughs.
Join us at 3BIGS and embark on a journey of innovation, discovery, and transformative drug development.
Together, we’ll shape the future of pharmaceutical research.
By seamlessly blending scientific expertise, advanced technologies, and a commitment to excellence, 3BIGS stands as the ultimate partner for your cheminformatics needs. Contact us today to revolutionize your drug discovery journey.